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KMID : 1216720110030010043
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Korean Journal of Gynecologic Endocrinology
2011 Volume.3 No. 1 p.43 ~ p.49
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Preliminary Study: The Body Compositional Change between Drospirenone (DRSP)Containing Low Dose Hormone Therapy and Tibolone
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Yuk Jin-Sung
Park Hyun-Tae
Yi Kyong-Wook
Kim Tak
Hur Jun-Young
Kim Sun-Haeng
Shin Jung-Ho
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Abstract
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Objectives: We compared the change of body composition and body size in according to tibolone and drospirenone
(DRSP) containing low dose hormone therapy in menopausal women.
Methods: Fifteen postmenopausal women were enrolled in this prospective study. The participants were randomly
assigned to either Tibolone group (2.5 mg daily; n=8) or EE+DRSP (Angeliq) group (estradiol hemihydrates 1
mg+DRSP 2 mg daily, n=7), drugs were given for 24 weeks. Twelve women completed the study protocol and
three women withdrew their participation. The body size and composition were measured with body mass index
(BMI), weight, waist circumference (WC) and hip circumference (HC) before and after intervention. The fat mass
(FM), fat-free mass (FFM), lean mass (LM) and total body water (TBW) were also measured by the Inbody 720
(Biospace, Korea) before and after intervention.
Results: After 24 weeks, the WC was significantly decreased in DRSP group (P=0.04). However, it was not
changed in the tibolone group (P=0.08). The fat-free mass, lean mass, body weight were increased in the tibolone
group, but not significantly (respectively P=0.12, P=0.17, P=0.08). The fat-free mass, lean mass were decreased but
not significantly, and body weight was not changed in DRSP group (respectively P=0.17, P=0.27, P=0.92).
Conclusion: EE+DRSP reduce WC without change in body weight in postmenopausal women. However, tibolone
made no significant change.
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KEYWORD
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Body composition, Drospirenone, Menopause, Tibolone, Waist circumference
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